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Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas

18 Jan 2019

Abstract excerpt

Abstract Breast adenomyoepitheliomas (AMEs) are rare epithelial-myoepithelial neoplasms that may occasionally produce myxochondroid matrix, akin to pleomorphic adenomas (PAs). Regardless of their anatomic location, PAs often harbor rearrangements involving HMGA2 or PLAG1. We have recently shown that the repertoire of somatic genetic alterations of AMEs varies according to their estrogen receptor (ER) status;...

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PMID: 30675516
DOI: 10.1038/s41523-018-0101-7

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