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Article

Interaction between ESRα polymorphisms and environmental factors in osteoporosis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Oct 2012

Sonoda Tomoko, Takada Junichi, Iba Kousuke, Asakura Sumiyo, Yamashita Toshihiko, Mori Mitsuru

Abstract excerpt

We hypothesized that environmental factors might affect the relationship between genetic predisposition and the risk of bone mineral density (BMD) loss. Cases were 114 Japanese women with a confirmed diagnosis of postmenopausal osteoporosis and controls were 171 general Japanese women. Genetic risk of SNPs in the estrogen receptors was analyzed by a case-control study. The interaction between gene and...

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PMID: 22328322
DOI: 10.1002/jor.22083

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