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Whole-genome sequencing of prostate cancer reveals novel mutation-driven processes and molecular subgroups.

Life sciences - 1 Aug 2020

Liang Caixia, Niu Lijuan, Xiao Zejun, Zheng Cuiling, Shen Yinchen, Shi Yuankai, Han Xiaohong

Abstract excerpt

Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. However, its genetic characteristics in the Chinese population have not been extensively profiled. Here we screened 27 Chinese patients and preformed whole-genome sequencing to dissect their genomic patterns. We found that 18.5% (5/27) tumors harbored non-protein coding mutations on FOXA1. Besides, novel focal amplifications/deletions...

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Identifiers

PMID: 31884093
DOI: 10.1016/j.lfs.2019.117218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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