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An LSEC-focused computational drug repurposing platform for liver fibrosis: Identification of vorinostat and other LSEC-protective candidates

2026-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Liver sinusoidal endothelial cells (LSECs) are increasingly recognized as a critical yet underexplored cell type in anti-fibrotic drug development. This study presents a computational drug screening platform integrating LSEC-specific transcriptomic analysis across simple steatosis, fibrotic nonalcoholic steatohepatitis (NASH), and cirrhosis, with tiered gene signature selection combining machine...

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Literature Corpus work
6efc3f3f-40d9-50f8-bb51-bd319f53c432
DOI
10.64898/2026.05.23.727430
Open publication

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An LSEC-focused computational drug repurposing platform for liver fibrosis: Identification of vorinostat and other LSEC-protective candidatesDOI 10.64898/2026.05.23.727430
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