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Article

Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats.

Gastroenterology - 1 Apr 2012

Xie Guanhua, Wang Xiangdong, Wang Lei, Wang Lin, Atkinson Roscoe D, Kanel Gary C, Gaarde William A, Deleve Laurie D

Abstract excerpt

BACKGROUND & AIMS: Capillarization, characterized by loss of differentiation of liver sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated whether restoration of LSEC differentiation would normalize crosstalk with activated hepatic stellate cells (HSC) and thereby promote quiescence of HSC and regression of fibrosis. METHODS: Rat LSECs were cultured with inhibitors and/or...

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Identifiers

PMID: 22178212
DOI: 10.1053/j.gastro.2011.12.017
PMCID: PMC3618963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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