Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.

doi:10.1371/journal.pone.0219724

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Article

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.

PloS one - 1 Jan 2019

Berens Michael E, Sood Anup, Barnholtz-Sloan Jill S, Graf John F, Cho Sanghee, Kim Seungchan, Kiefer Jeffrey, Byron Sara A, Halperin Rebecca F, Nasser Sara, Adkins Jonathan, Cuyugan Lori, Devine Karen, Ostrom Quinn, Couce Marta, Wolansky Leo, McDonough Elizabeth, Schyberg Shannon, Dinn Sean, Sloan Andrew E, Prados Michael, Phillips Joanna J, Nelson Sarah J, Liang Winnie S, Al-Kofahi Yousef, Rusu Mirabela, Zavodszky Maria I, Ginty Fiona

Abstract excerpt

Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated IDH1 mutant (mt) vs wildtype (wt) forms of glioma, we integrated data from protein, genomic and MR imaging from 20 treatment-naïve glioma cases and 16 recurrent GBM cases....

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PMID: 31881020
DOI: 10.1371/journal.pone.0219724
PMCID: PMC6934292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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