Article

Melatonin Enhances Osteoblastogenesis from Senescent Mesenchymal Stem Cells via MMSET Mediated Chromatin Remodeling

2021-01-04

Abstract excerpt

<title>Abstract</title> <p>Large numbers of elderly people have aging-associated osteoporosis, but efficient approaches to ameliorate bone loss are limited due to our poor understanding of the underlying mechanisms. In this study, we found that melatonin levels in bone marrow decreased with age, and melatonin primarily enhanced the osteogenic potential of mesenchymal stem cells (MSCs) derived from elderly donors...

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Literature Corpus work: d3304c14-7ea4-5092-b0e9-2670ca722546
DOI: 10.21203/rs.3.rs-130548/v1

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