Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic therapy attenuates oxidative stress in BMSCs during ageing

7 Dec 2021

Abstract excerpt

Oxidative stress, a hallmark of ageing, inhibits the osteogenic differentiation of bone marrow-derived mesenchymal stem cells in long bone. The dysfunction of the cellular antioxidant defence system is a critical cause of oxidative stress, but the mechanism of the decline of antioxidant defence in senescent stem cells remains elusive. Here, we found that EZH2, an epigenetic regulator of histone methylation, acted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34874118
DOI: 10.1111/jcmm.17089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic therapy attenuates oxidative stress in BMSCs during ageingPMID 34874118Read ↗

Epigenetic therapy targeting bone marrow mesenchymal stem cells for age-related bone diseasesSemantic proximity Read ↗

Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2‐mediated chromatin remodellingSemantic proximity Read ↗

UBE2E3 regulates cellular senescence and osteogenic differentiation of BMSCs during agingSemantic proximity Read ↗

Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and OsteoporosisSemantic proximity Read ↗

Epigenetic regulation of mesenchymal stem cell aging through histone modificationsSemantic proximity Read ↗

Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal AgingSemantic proximity Read ↗

Melatonin Enhances Osteoblastogenesis from Senescent Mesenchymal Stem Cells via MMSET Mediated Chromatin RemodelingSemantic proximity Read ↗

Epigenetic control of mesenchymal stem cells orchestrates bone regenerationSemantic proximity Read ↗

Epigenetic Alterations under Oxidative Stress in Stem CellsSemantic proximity Read ↗

Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during AgingSemantic proximity Read ↗

Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and AdipocytesSemantic proximity Read ↗

1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.