Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD

Abstract excerpt

BACKGROUND: Hedgehog (HH) pathway is constantly under scrutiny in the context of organ development. Lung morphogenesis requires HH signalling which participates thereafter to the pulmonary homeostasis by regulating epithelial cell quiescence and repair. Since epithelial remodelling is a hallmark of Chronic Obstructive Pulmonary Disease (COPD), we investigated whether the main molecular actors of HH pathway...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Cells and Metastasis
• Share to Hedgehog Signaling Pathway Studies
• Share to Neonatal Respiratory Health Research