Article
The hedgehog system machinery controls transforming growth factor-β-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis.
The American journal of pathology - 1 Dec 2012
Cigna Natacha, Farrokhi Moshai Elika, Brayer Stéphanie, Marchal-Somme Joëlle, Wémeau-Stervinou Lidwine, Fabre Aurélie, Mal Hervé, Lesèche Guy, Dehoux Monique, Soler Paul, Crestani Bruno, Mailleux Arnaud A
Abstract excerpt
Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown cause. Key signaling developmental pathways are aberrantly expressed in IPF. The hedgehog pathway plays a key role during fetal lung development and may be involved in lung fibrogenesis. We determined the expression pattern of several Sonic hedgehog (SHH) pathway members in normal and IPF human lung biopsies and primary fibroblasts. The...
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