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Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling

28 May 2022

Abstract excerpt

The development of the embryonic lung demands complex endodermal-mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development. It plays a key regulatory role during several morphogenic mechanisms, such as cell growth, differentiation, migration, and persistence of cells. On the other hand, abnormal expression or loss of regulation of Hh...

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PMID: 35681469
DOI: 10.3390/cells11111774

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