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Article

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype

12 Jul 2018

Abstract excerpt

GWAS have repeatedly mapped susceptibility loci for emphysema to genes that modify hedgehog signaling, but the functional relevance of hedgehog signaling to this morbid disease remains unclear. In the current study, we identified a broad population of mesenchymal cells in the adult murine lung receptive to hedgehog signaling, characterized by higher activation of hedgehog surrounding the proximal airway relative...

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PMID: 29999500
DOI: 10.1172/jci99435

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