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Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy

26 Dec 2019

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease in which the dystrophin coding for a membrane stabilizing protein is mutated.Recently, the vasculature has also shown to be perturbed in DMD and DMD model mdx mice.Recent DMD transcriptomics revealed the defects were correlated to a vascular endothelial growth factor (VEGF) signaling pathway.To reveal the relationship between DMD and VEGF...

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PMID: 31877123
DOI: 10.1371/journal.pgen.1008468

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