Article

Voluntary Running Sustains the Correction of Inflammation-Related Gene Expression Conferred by AAV Gene Therapy in Mdx Mice

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Duchenne Muscular Dystrophy is a fatal disease characterized by persistent skeletal muscle degeneration, inflammation, and fibrosis. Gene therapy using an adeno-associated virus derived vector and a microdystrophin transgene is currently under investigation in patients but the impact of physical activity on long-term therapeutic outcome remains poorly understood. Recently, we reported 21-weeks o...

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Literature Corpus work: 0101588f-e614-5076-9db3-ed2017bd7b99
DOI: 10.1101/2025.01.17.633557

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