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Article

Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice.

Human molecular genetics - 1 Nov 2010

Verma Mayank, Asakura Yoko, Hirai Hiroyuki, Watanabe Shuichi, Tastad Christopher, Fong Guo-Hua, Ema Masatsugu, Call Jarrod A, Lowe Dawn A, Asakura Atsushi

Abstract excerpt

Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease caused by mutations in the gene coding for the protein dystrophin. Recent work demonstrates that dystrophin is also found in the vasculature and its absence results in vascular deficiency and abnormal blood flow. This induces a state of ischemia further aggravating the muscular dystrophy pathogenesis. For an effective form of therapy of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Vascular Endothelial Growth Factor Receptor-1

Source

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Identifiers

PMID: 20705734
DOI: 10.1093/hmg/ddq334
PMCID: PMC2951865

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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