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Article

Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation.

ACS chemical biology - 17 Jan 2020

Mahasenan Kiran V, Batuecas María T, De Benedetti Stefania, Kim Choon, Rana Neha, Lee Mijoon, Hesek Dusan, Fisher Jed F, Sanz-Aparicio Julia, Hermoso Juan A, Mobashery Shahriar

Abstract excerpt

BglX is a heretofore uncharacterized periplasmic glycoside hydrolase (GH) of the human pathogen Pseudomonas aeruginosa. X-ray analysis identifies it as a protein homodimer. The two active sites of the homodimer comprise catalytic residues provided by each monomer. This arrangement is seen in <2% of the hydrolases of known structure. In vitro substrate profiling shows BglX is a catalyst for β-(1→2) and β-(1→3)...

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Identifiers

PMID: 31877028
DOI: 10.1021/acschembio.9b00754
PMCID: PMC7995829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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