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<i>Pseudomonas aeruginosa</i> LasR-deficient mutants have increased methylglyoxal and hydrogen peroxide sensitivity due to low intracellular glutathione

2024-09-25

Abstract excerpt

The electrophile methylglyoxal (MG) is produced by microorganisms and host cells through central metabolic pathways. MG is a highly reactive electrophile, so it must be rapidly detoxified to prevent damaging modifications to macromolecules. Pseudomonas aeruginosa , a pathogen of concern due to its ability develop multidrug resistance, causes many types of infections that have been associated with elevated MG leve...

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Literature Corpus work
f25ccac4-0aaf-5a7c-81da-8948d2a20421
DOI
10.1101/2024.09.25.615034
Open publication

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<i>Pseudomonas aeruginosa</i> LasR-deficient mutants have increased methylglyoxal and hydrogen peroxide sensitivity due to low intracellular glutathioneDOI 10.1101/2024.09.25.615034
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