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Article

Molecular modeling and redesign of alginate lyase from Pseudomonas aeruginosa for accelerating CRPA biofilm degradation.

Proteins - 1 Dec 2016

Cho Hoon, Huang Xiaoqin, Lan Piao Yu, Eun Kim Da, Yeon Lee So, Jeong Yoon Eun, Hee Park So, Lee Kyoung, Ho Jang Chul, Zhan Chang-Guo

Abstract excerpt

Administration of an efficient alginate lyase (AlgL) or AlgL mutant may be a promising therapeutic strategy for treatment of cystic fibrosis patients with Pseudomonas aeruginosa infections. Nevertheless, the catalytic activity of wild-type AlgL is not sufficiently high. It is highly desired to design and discover an AlgL mutant with significantly improved catalytic efficiency against alginate substrates. For the...

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PMID: 27676452
DOI: 10.1002/prot.25171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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