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Article

Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 21 Feb 2020

Bryson Duncan, Hettle Andrew G, Boraston Alisdair B, Hobbs Joanne K

Abstract excerpt

Antibiotic tolerance is an underappreciated antibiotic escape strategy that is associated with recurrent and relapsing infections, as well as acting as a precursor to resistance. Tolerance describes the ability of a bacterial population to survive transient exposure to an otherwise lethal concentration of antibiotic without exhibiting an elevated MIC. It is detected in time-kill assays as a lower rate of killing...

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Source

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Identifiers

PMID: 31871080
DOI: 10.1128/AAC.02103-19
PMCID: PMC7038295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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