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Article

Clinical rel mutations in Staphylococcus aureus prime pathogen expansion under nutrient stress.

mSphere - 24 Oct 2023

Chen Edwin, Shaffer Marla G, Bilodeau Robert E, West Raymond E, Oberly Patrick J, Nolin Thomas D, Culyba Matthew J

Abstract excerpt

Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein. Rel synthesizes (p)ppGpp "alarmones" in response to amino acid starvation, which enables adaptation to stress by modulating bacterial growth and virulence. We previously identified five novel protein-altering mutations in rel that arose in...

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Identifiers

PMID: 37750686
DOI: 10.1128/msphere.00249-23
PMCID: PMC10597345

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