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Article

Molecular Characterization of Clinical Rel Mutations and Consequences for Resistance Expression and Fitness in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 20 Dec 2022

Deventer Ashley T, Bryson Duncan, Shortill Mathew, Boraston Alisdair B, Hobbs Joanne K

Abstract excerpt

The stringent response (SR) is a universal stress response that acts as a global regulator of bacterial physiology and virulence, and is a contributor to antibiotic tolerance and resistance. In most bacteria, the SR is controlled by a bifunctional enzyme, Rel, which both synthesizes and hydrolyzes the alarmone (p)ppGpp via two distinct catalytic domains. The balance between these antagonistic activities is...

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PMID: 36346240
DOI: 10.1128/aac.00938-22
PMCID: PMC9764984

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