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Article

Is cellular senescence an example of antagonistic pleiotropy?

14 Feb 2012

Abstract excerpt

It is generally accepted that the permanent arrest of cell division known as cellular senescence contributes to aging by an antagonistic pleiotropy mechanism: cellular senescence would act beneficially early in life by suppressing cancer, but detrimentally later on by causing frailty and, paradoxically, cancer. In this review, we show that there is room to rethink this common view. We propose a critical appraisal...

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PMID: 22329645
DOI: 10.1111/j.1474-9726.2012.00807.x

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