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Article

Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.

ACS chemical biology - 21 Feb 2020

Pang Luping, Nautiyal Manesh, De Graef Steff, Gadakh Bharat, Zorzini Valentina, Economou Anastassios, Strelkov Sergei V, Van Aerschot Arthur, Weeks Stephen D

Abstract excerpt

The pyrimidine-containing Trojan horse antibiotics albomycin and a recently discovered cytidine-containing microcin C analog target the class II seryl- and aspartyl-tRNA synthetases (serRS and aspRS), respectively. The active components of these compounds are competitive inhibitors that mimic the aminoacyl-adenylate intermediate. How they effectively substitute for the interactions mediated by the canonical...

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PMID: 31869198
DOI: 10.1021/acschembio.9b00887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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