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Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics

24 Mar 2022

Abstract excerpt

The widespread emergence of antibiotic-resistant bacteria highlights the urgent need for new antimicrobial agents. Albomycins are a group of naturally occurring sideromycins with a thionucleoside antibiotic conjugated to a ferrichrome-type siderophore. The siderophore moiety serves as a vehicle to deliver albomycins into bacterial cells via a "Trojan horse" strategy. Albomycins function as specific inhibitors of...

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PMID: 35453190
DOI: 10.3390/antibiotics11040438

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