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Article

CBS gene polymorphism and promoter methylation-mediating effects on the efficacy of folate therapy in patients with hyperhomocysteinemia.

The journal of gene medicine - 1 Apr 2020

Zhao Qinglin, Zhang Chengda, Li Dankang, Huang Xiaowen, Ren Bingnan, Yue Limin, Du Binghui, Godfrey Opolot, Zhang Weidong

Abstract excerpt

BACKGROUND: A decrease in cystathionine beta-synthase (CBS) enzyme activity could lead to hyperhomocysteinemia (HHcy). Studies have revealed that DNA methylation has a mediating effect on the development of diseases. The present study aimed to explore CBS promoter methylation-mediating effects on the efficacy of folate treatment for HHcy. METHODS: HHcy patients were treated with folate (5 mg/day) for 90 days and...

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Identifiers

PMID: 31864233
DOI: 10.1002/jgm.3156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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