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Article

Folate Deficiency and Gene Polymorphisms of MTHFR, MTR and MTRR Elevate the Hyperhomocysteinemia Risk.

Clinical laboratory - 1 Mar 2017

Li Wen-Xing, Cheng Fei, Zhang A-Jie, Dai Shao-Xing, Li Gong-Hua, Lv Wen-Wen, Zhou Tao, Zhang Qiang, Zhang Hong, Zhang Tao, Liu Fang, Liu Dahai, Huang Jing-Fei

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). We aimed to investigate the joint effect of homocysteine metabolism gene polymorphisms, as well as the folate deficiency on the risk of HHcy in a Chinese hypertensive population. METHODS: This study enrolled 480 hypertensive patients aged 28 - 75 from six hospitals in different Chinese regions from 9/2005 -...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Ferredoxin-NADP Reductase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Homocysteine

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 28271696
DOI: 10.7754/Clin.Lab.2016.160917

Genes

MTHFR
MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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