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Article

MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.

Cancer discovery - 1 Mar 2014

Romero Octavio A, Torres-Diz Manuel, Pros Eva, Savola Suvi, Gomez Antonio, Moran Sebastian, Saez Carmen, Iwakawa Reika, Villanueva Alberto, Montuenga Luis M, Kohno Takashi, Yokota Jun, Sanchez-Cespedes Montse

Abstract excerpt

Our knowledge of small cell lung cancer (SCLC) genetics is still very limited, amplification of L-MYC, N-MYC, and C-MYC being some of the well-established gene alterations. Here, we report our discovery of tumor-specific inactivation of the MYC-associated factor X gene, MAX, in SCLC. MAX inactivation is mutually exclusive with alterations of MYC and BRG1, the latter coding for an ATPase of the switch/sucrose...

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Source

Identifiers

PMID: 24362264
DOI: 10.1158/2159-8290.CD-13-0799

Genes

MAX
MYC
MGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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