Article
Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.
Molecular and cellular biology - 1 Feb 2004
Nilsson Jonas A, Maclean Kirsteen H, Keller Ulrich B, Pendeville Helene, Baudino Troy A, Cleveland John L
Abstract excerpt
Myc oncoproteins are overexpressed in most cancers and are sufficient to accelerate cell proliferation and provoke transformation. However, in normal cells Myc also triggers apoptosis. All of the effects of Myc require its function as a transcription factor that dimerizes with Max. This complex induces genes containing CACGTG E-boxes, such as Ornithine decarboxylase (Odc), which harbors two of these elements....
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