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Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis

13 Oct 2017

Abstract excerpt

Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor function, it is less clear how ST contributes to MCC tumorigenesis. Here we show that ST binds specifically to the MYC homolog MYCL (L-MYC) and recruits it to the...

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PMID: 29028833
DOI: 10.1371/journal.ppat.1006668

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