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Article

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.

JAMA neurology - 1 Apr 2020

Therriault Joseph, Benedet Andrea L, Pascoal Tharick A, Mathotaarachchi Sulantha, Chamoun Mira, Savard Melissa, Thomas Emilie, Kang Min Su, Lussier Firoza, Tissot Cecile, Parsons Marlee, Qureshi Muhammad Naveed Iqbal, Vitali Paolo, Massarweh Gassan, Soucy Jean-Paul, Rej Soham, Saha-Chaudhuri Paramita, Gauthier Serge, Rosa-Neto Pedro

Abstract excerpt

Importance: Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for Alzheimer disease. While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial. Objective: To determine whether APOEε4 is associated with medial temporal tau pathology independently of amyloid-β, sex, clinical status, and age. Design, Setting, and...

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Identifiers

PMID: 31860000
DOI: 10.1001/jamaneurol.2019.4421
PMCID: PMC6990684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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