Article
Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing.
BMC cancer - 25 Jul 2020
Zhao Yue, He Jun Ying, Cui Jun Zhao, Meng Zi-Qi, Zou Yue Li, Guo Xiao Su, Chen Xin, Wang Xueliang, Yan Li-Tian, Han Wei Xin, Li Chunyan, Guo Li, Bu Hui
Abstract excerpt
BACKGROUND: This study profiled the somatic genes mutations and the copy number variations (CNVs) in cerebrospinal fluid (CSF)-circulating tumor DNA (ctDNA) from patients with neoplastic meningitis (NM). METHODS: A total of 62 CSF ctDNA samples were collected from 58 NM patients for the next generation sequencing. The data were bioinformatically analyzed by (Database for Annotation, Visualization and Integrated...
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