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Article

Evaluating Infectious, Neoplastic, Immunological, and Degenerative Diseases of the Central Nervous System with Cerebrospinal Fluid-Based Next-Generation Sequencing.

Molecular diagnosis & therapy - 1 Mar 2021

Tsamis Konstantinos I, Sakkas Hercules, Giannakis Alexandros, Ryu Han Suk, Gartzonika Constantina, Nikas Ilias P

Abstract excerpt

Cerebrospinal fluid (CSF) is a clear and paucicellular fluid that circulates within the ventricular system and the subarachnoid space of the central nervous system (CNS), and diverse CNS disorders can impact its composition, volume, and flow. As conventional CSF testing suffers from suboptimal sensitivity, this review aimed to evaluate the role of next-generation sequencing (NGS) in the work-up of infectious,...

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Identifiers

PMID: 33646562
DOI: 10.1007/s40291-021-00513-x
PMCID: PMC7917176

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