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In Vivo Relationship between the Nano-Biomechanical Properties of Streptococcal Polysaccharide Capsules and Virulence Phenotype.

ACS nano - 28 Jan 2020

Marshall Helina, Aguayo Sebastian, Kilian Mogens, Petersen Fernanda, Bozec Laurent, Brown Jeremy

Abstract excerpt

In common with many bacterial pathogens, Streptococcus pneumoniae has a polysaccharide capsule which facilitates immune evasion and determines virulence. Recent data have shown that the closely related Streptococcus mitis also expresses polysaccharide capsules including those with an identical chemical structure to S. pneumoniae capsular serotypes. We utilized atomic force microscopy (AFM) techniques to...

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PMID: 31854972
DOI: 10.1021/acsnano.9b08631

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