Article
The major surface-associated saccharides of Klebsiella pneumoniae contribute to host cell association.
PloS one - 1 Jan 2008
Clements Abigail, Gaboriaud Fabien, Duval Jérôme F L, Farn Jacinta L, Jenney Adam W, Lithgow Trevor, Wijburg Odilia L C, Hartland Elizabeth L, Strugnell Richard A
Abstract excerpt
Analysing the pathogenic mechanisms of a bacterium requires an understanding of the composition of the bacterial cell surface. The bacterial surface provides the first barrier against innate immune mechanisms as well as mediating attachment to cells/surfaces to resist clearance. We utilised a series of Klebsiella pneumoniae mutants in which the two major polysaccharide layers, capsule and lipopolysaccharide...
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