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Identification of a functional capsule locus in Streptococcus mitis

24 Dec 2011

Abstract excerpt

The polysaccharide capsule of Streptococcus pneumoniae is a hallmark for virulence in humans. In its close relative Streptococcus mitis, a common human commensal, analysis of the sequenced genomes of six strains revealed the presence of a putative capsule locus in four of them. We constructed an isogenic S. mitis mutant from the type strain that lacked the 19 open reading frames in the capsule locus (Δcps...

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PMID: 22394468
DOI: 10.1111/j.2041-1014.2011.00635.x

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