Article
Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C Virus.
Viruses - 3 Apr 2021
García-Crespo Carlos, Gallego Isabel, Soria María Eugenia, de Ávila Ana Isabel, Martínez-González Brenda, Vázquez-Sirvent Lucía, Lobo-Vega Rebeca, Moreno Elena, Gómez Jordi, Briones Carlos, Gregori Josep, Quer Josep, Domingo Esteban, Perales Celia
Abstract excerpt
Replication of RNA viruses is characterized by exploration of sequence space which facilitates their adaptation to changing environments. It is generally accepted that such exploration takes place mainly in response to positive selection, and that further diversification is boosted by modifications of virus population size, particularly bottleneck events. Our recent results with hepatitis C virus (HCV) have shown...
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