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Article

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase.

Cell reports - 17 Dec 2019

Soma Shivatheja, Morgada Marcos N, Naik Mandar T, Boulet Aren, Roesler Anna A, Dziuba Nathaniel, Ghosh Alok, Yu Qinhong, Lindahl Paul A, Ames James B, Leary Scot C, Vila Alejandro J, Gohil Vishal M

Abstract excerpt

In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX2, is a complex process that requires metallochaperones and redox proteins including SCO1, SCO2, and COA6, a recently discovered protein whose molecular function is unknown....

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Identifiers

PMID: 31851937
DOI: 10.1016/j.celrep.2019.11.054
PMCID: PMC6946597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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