Article

The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif

2025-03-25

Abstract excerpt

The cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental processes such as DNA replication and repair. Up to 25% of these client proteins terminate in a targeting complex recognition (TCR) motif. This carboxy-terminal tripeptide motif recruits the CIA targeting complex (CTC) to the...

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Literature Corpus work: 29d8aa69-3078-5962-91c7-8c2fcd9dbd33
DOI: 10.1101/2025.03.25.645274

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The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motifDOI 10.1101/2025.03.25.645274Read

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