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Article

Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein.

The Journal of biological chemistry - 15 Apr 2005

Williams John C, Sue Carolyn, Banting Graham S, Yang Hua, Glerum D Moira, Hendrickson Wayne A, Schon Eric A

Abstract excerpt

Human SCO1 and SCO2 are copper-binding proteins involved in the assembly of mitochondrial cytochrome c oxidase (COX). We have determined the crystal structure of the conserved, intermembrane space core portion of apo-hSCO1 to 2.8 A. It is similar to redox active proteins, including thioredoxins (Trx) and peroxiredoxins (Prx), with putative copper-binding ligands located at the same positions as the conserved...

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Source

Identifiers

PMID: 15659396
DOI: 10.1074/jbc.M410705200

Genes

SCO1
SCO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein.PMID 15659396Read ↗

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