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Article

Mutational landscape of high-grade B-cell lymphoma with MYC-, BCL2 and/or BCL6 rearrangements characterized by whole-exome sequencing.

Haematologica - 1 Aug 2022

Künstner Axel, Witte Hanno M, Riedl Jörg, Bernard Veronica, Stölting Stephanie, Merz Hartmut, Olschewski Vito, Peter Wolfgang, Ketzer Julius, Busch Yannik, Trojok Peter, Bubnoff Nikolas von, Busch Hauke, Feller Alfred C, Gebauer Niklas

Abstract excerpt

High-grade B-cell lymphoma accompanied with double/triple-hit MYC and BCL2 and/or BCL6 rearrangements (HGBLDH/ TH) poses a cytogenetically-defined provisional entity among aggressive B-cell lymphomas that is traditionally associated with unfavorable prognosis. In order to better understand the mutational and molecular landscape of HGBLDH/ TH we here performed whole-exome sequencing and deep panel next-generation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Share to Proto-Oncogene Proteins c-bcl-2

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Identifiers

PMID: 34788985
DOI: 10.3324/haematol.2021.279631
PMCID: PMC9335106

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