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Article

The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma.

Current hematologic malignancy reports - 1 Sept 2013

Lin Pei, Medeiros L Jeffrey

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is heterogeneous. Gene expression profiling (GEP) has identified two principal subtypes: germinal center B cell (GCB) and activated B cell (ABC). Most DLBCL cases are distinct from Burkitt lymphoma (BL), but a subset of tumors has a GEP profile between BL and DLBCL, suggesting a spectrum. In parallel, the 2008 World Health Organization (WHO) classification included the...

Topics

Antineoplastic Combined Chemotherapy Protocols
Gene Rearrangement
Genes, myc
Genetic Predisposition to Disease
Humans
Lymphoma, Large B-Cell, Diffuse
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23892979
DOI: 10.1007/s11899-013-0169-y

Genes

MYC
BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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