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Article

Fitting double-hit lymphoma into the aggressive lymphoma spectrum: a square peg in a round hole?

Leukemia & lymphoma - 1 May 2022

Gordon Max J, Westin Jason R

Abstract excerpt

High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements or both, commonly called double-hit lymphoma (DHL), is an aggressive B-cell lymphoma that is molecularly distinct from diffuse large B-cell lymphoma (DLBCL) and is associated with poor outcomes. Recent advances in the molecular classification of DLBCL have identified distinct subsets, including genetic signatures which correlate with DHL and...

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Identifiers

PMID: 34842019
DOI: 10.1080/10428194.2021.2008383

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