Regulation of Fibroblast Activation Protein-α Expression: Focus on Intracellular Protein Interactions

Abstract excerpt

The prolyl-specific peptidase fibroblast activation protein-α (FAP-α) is expressed at very low or undetectable levels in nondiseased human tissues but is selectively induced in activated (myo)fibroblasts at sites of tissue remodeling in fibrogenic processes. In normal regenerative processes involving transient fibrosis FAP-α + (myo)fibroblasts disappear from injured tissues, replaced by cells with a normal FAP-α...

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