Article
P311-induced myofibroblasts exhibit ameboid-like migration through RalA activation.
Experimental cell research - 15 Oct 2006
Shi Jinghua, Badri Kameswara Rao, Choudhury Ranginee, Schuger Lucia
Abstract excerpt
We previously showed that P311, an intracellular protein involved in cell migration, is found in human wound myofibroblast precursors (proto-myofibroblasts) and myofibroblasts. Furthermore, by binding to the TGF-beta1 latency associated protein (LAP), P311 induced NIH 3T3 cells to transform into non-fibrogenic myofibroblasts characterized by lack of TGF-beta1 production. Here we demonstrate that P311-induced...
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