Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The MC4R p.Ile269Asn mutation confers a high risk for type 2 diabetes in the Mexican population via obesity dependent and independent effects.

Scientific reports - 4 Feb 2021

Vázquez-Moreno Miguel, Locia-Morales Daniel, Valladares-Salgado Adan, Sharma Tanmay, Perez-Herrera Aleyda, Gonzalez-Dzib Roxana, Rodríguez-Ruíz Francisco, Wacher-Rodarte Niels, Cruz Miguel, Meyre David

Abstract excerpt

We investigated the association between the loss-of-function mutation MC4R p.Ile269Asn and T2D risk in the Mexican population. We enrolled 6929 adults [3175 T2D cases and 3754 normal glucose tolerant (NGT) controls] and 994 NGT children in the study. Anthropometric data and T2D-related quantitative traits were studied in 994 NGT children and 3754 NGT adults. The MC4R p.Ile269Asn mutation was genotyped using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Mass Index
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genetic Predisposition to Disease

Share to Obesity

Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 4

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33542413
DOI: 10.1038/s41598-021-82728-w
PMCID: PMC7862248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The MC4R p.Ile269Asn mutation confers a high risk for type 2 diabetes in the Mexican population via obesity dependent and independent effects.PMID 33542413Read ↗

The Melanocortin 4 Receptor p.Ile269Asn Mutation Is Associated with Childhood and Adult Obesity in Mexicans.Semantic proximity Read ↗

Sex/Gender Modifies the Association Between the MC4R p.Ile269Asn Mutation and Type 2 Diabetes in the Mexican Population.Semantic proximity Read ↗

Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity.Semantic proximity Read ↗

Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population.Semantic proximity Read ↗

Naturally occurring mutations in G protein-coupled receptors associated with obesity and type 2 diabetes mellitus.Semantic proximity Read ↗

Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.Semantic proximity Read ↗

MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes.Semantic proximity Read ↗

Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes.Semantic proximity Read ↗

The association between leptin receptor gene polymorphisms and type 2 diabetes mellitus: A systematic review and meta-analysis.Semantic proximity Read ↗

Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.Semantic proximity Read ↗

Exploring the Association of FTO rs9939609 with Type 2 Diabetes, Fasting Glucose and HbA1c in a Southeastern Mexican Region of Predominant Mayan Genetic Background.Semantic proximity Read ↗

TCF7L2 rs7903146 polymorphism association with diabetes and obesity in an elderly cohort from BrazilSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.