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Article

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Eswarakumar Veraragavan P, Schlessinger Joseph

Abstract excerpt

Fibroblast growth factor receptor 3 (FGFR3) plays an important role in the control of chondrocyte proliferation and differentiation, a process critical for normal development of the skeleton. To reveal the contributions of the epithelial Fgfr3b isoform and the mesenchymal Fgfr3c isoform to skeletal overgrowth seen in mice, in which both isoforms have been inactivated (Fgf3c(-/-) mice), we have generated mice in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17360456
DOI: 10.1073/pnas.0700012104
PMCID: PMC1820687

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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