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Article

Is Peripheral BDNF Promoter Methylation a Preclinical Biomarker of Dementia?

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Fransquet Peter D, Ritchie Karen, Januar Vania, Saffery Richard, Ancelin Marie-Laure, Ryan Joanne

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) has been implicated in dementia. Preliminary evidence suggests that BDNF DNA methylation may be a diagnostic biomarker of dementia, but the potential pre-clinical utility remains unclear. Participants in the ESPRIT study were assessed for cognitive function and dementia (DSM-IV criteria) over 14 years. BDNF exon 1 promoter methylation was measured in blood at baseline...

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Identifiers

PMID: 31839607
DOI: 10.3233/JAD-190738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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