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DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Xie Bing, Liu Zanchao, Liu Wenxuan, Jiang Lei, Zhang Rui, Cui Dongsheng, Zhang Qingfu, Xu Shunjiang

Abstract excerpt

Alzheimer's disease (AD) is a complex multifactorial disease influenced by both genetic and epigenetic factors. This study was aimed to evaluate the interaction between brain-derived neurotrophic factor (BDNF) promoter methylation status and tag single nucleotide polymorphisms (tag SNPs) on amnestic mild cognitive impairment (aMCI) and its conversion to AD. A total of 506 aMCI patients and 728 cognitive normal...

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Identifiers

PMID: 28387675
DOI: 10.3233/JAD-170007

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BDNF

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