Article
Function and phenotype of microglia are determined by toll-like receptor 2/toll-like receptor 4 activation sequence.
DNA and cell biology - 1 Oct 2009
Li Weixin, Gao Guodong, Guo Qingdong, Jia Dong, Wang Julei, Wang Xuelian, He Shiming, Liang Qinchuan
Abstract excerpt
Toll-like receptors (TLRs) initiate and maintain host defenses. These receptors play important roles in innate immunity and in various diseases. Different TLRs bind to diverse ligands that trigger distinct protein expression patterns. Few studies have focused on the interaction between different TLRs. We found that TLR2 priming downregulates TLR4 transcription, and expression of TLR4 activation induced major...
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