Article
High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma.
Genes, chromosomes & cancer - 1 Nov 2011
Wang Xiaoke, Asmann Yan W, Erickson-Johnson Michele R, Oliveira Jennifer L, Zhang Hongying, Moura Rafael D, Lazar Alexander J, Lev Dina, Bill Katelynn, Lloyd Ricardo V, Yaszemski Michael J, Maran Avudaiappan, Oliveira Andre M
Abstract excerpt
Well-differentiated liposarcoma (WDLS) is one of the most common malignant mesenchymal tumors and dedifferentiated liposarcoma (DDLS) is a malignant tumor consisting of both WDLS and a transformed nonlipogenic sarcomatous component. Cytogenetically, WDLS is characterized by the presence of ring or giant rod chromosomes containing several amplified genes, including MDM2, TSPAN31, CDK4, and others mainly derived...
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